Dr David van Bockel

Senior Research Officer

Bachelor of Biotechnology (Hons), PhD (St Vincent's Clinical School)

Medicine & Health

The Kirby Institute

David is a post-doctoral research scientist investigating the co-morbidities of viral infection. His primary interests are quantifying immune traits that lead to disease and quantifying how people react to pathogens including human immunodeficiency virus (HIV-1), papillomavirus (HPV) and tuberculosis either during natural infection or undergoing treatment.

Phone

+61 2 9385 0471

E-mail

dvanbockel@kirby.unsw.edu.au

Journal articles | 2023

Cook L; Zaunders J; Seddiki N; van Bockel D; Kelleher AD; Munier CML, 2023, 'Parallel analysis of multiple human memory CD4+ T-cell subsets within antigen-specific responses using cell proliferation dyes', Immunology and Cell Biology, 101, pp. 171 - 178,

Journal articles | 2023

van Bockel D; Kelleher A, 2023, 'The crossroads: divergent roles of virus-specific CD4+ T lymphocytes in determining the outcome for human papillomavirus infection', Immunology and Cell Biology, 101, pp. 525 - 534,

Journal articles | 2022

Boyd MA; van Bockel D; Munier CML; Kelleher AD, 2022, 'Navigating the complexity of chronic HIV-1 associated immune dysregulation', Current Opinion in Immunology, 76,

Journal articles | 2020

Cook L; Munier CML; Seddiki N; Hardy MY; Anderson RP; Zaunders J; Tye-Din JA; Kelleher AD; van Bockel D, 2020, 'Circulating gluten-specific, but not CMV-specific, CD39+ regulatory T cells have an oligoclonal TCR repertoire', Clinical and Translational Immunology, 9, pp. e1096,

Journal articles | 2020

Nikolayevskyy V; Balabanova Y; Kontsevaya I; Ignatyeva O; Skenders G; Vasiliauskiene E; Bockel DV; Drobniewski F, 2020, 'Biomarkers of treatment success in fully sensitive pulmonary tuberculosis patients: A multicenter longitudinal study', Biomarkers in Medicine, 14, pp. 1439 - 1452,

Journal articles | 2020

Van Bockel D; Munier CML; Turville S; Badman SG; Walker G; Stella AO; Aggarwal A; Yeang M; Condylios A; Kelleher AD; Applegate TL; Vallely A; Whiley D; Rawlinson W; Cunningham P; Kaldor J; Guy R, 2020, 'Evaluation of commercially available viral transport medium (VTM) for SARS-CoV-2 inactivation and use in point-of-care (POC) testing', Viruses, 12, pp. 1208,

Journal articles | 2019

Hey-Nguyen WJ; Bailey M; Xu Y; Suzuki K; Van Bockel D; Finlayson R; Leigh Brown A; Carr A; Cooper DA; Kelleher AD; Koelsch KK; Zaunders JJ, 2019, 'HIV-1 DNA Is Maintained in Antigen-Specific CD4+ T Cell Subsets in Patients on Long-Term Antiretroviral Therapy Regardless of Recurrent Antigen Exposure', AIDS Research and Human Retroviruses, 35, pp. 112 - 120,

Journal articles | 2019

Polizzotto M; Van Bockel D; Law C; Roberts J; Buckland G; Just S; Comben S; Hillman R; Gilson R; Pett S; Poynten M; Law M; Kelleher A; Emery S, 2019, 'Clearance of HPV Anal Premalignant Lesions and Modulation of Systemic Immune Responses to HPV Oncogenes with Low Dose Pomalidomide', Annals of Oncology, 30, pp. xi35 - xi35,

Journal articles | 2018

Kent SJ; Hough S; Kelleher AD; Law MG; Hutchinson J; Catalfarmo M; van Bockel D; Lane C; Baker JV; Emery S; Han A, 2018, 'Vorapaxar for HIV-associated inflammation and coagulopathy (ADVICE): a randomised, double-blind, placebo-controlled trial', Lancet HIV, 5, pp. e553 - e559,

Journal articles | 2017

Cook L; Munier CML; Seddiki N; van Bockel D; Ontiveros N; Hardy MY; Gillies JK; Levings MK; Reid HH; Petersen J; Rossjohn J; Anderson RP; Zaunders JJ; Tye-Din JA; Kelleher AD, 2017, 'Circulating gluten-specific FOXP3+CD39+ regulatory T cells have impaired suppressive function in patients with celiac disease', Journal of Allergy and Clinical Immunology, 140, pp. 1592 - 1603.e8,

Journal articles | 2017

Juno JA; Bockel DV; Kent SJ; Kelleher AD; Zaunders JJ; Munier CML, 2017, 'Cytotoxic CD4 T cells-friend or foe during viral infection?', Frontiers in Immunology, 8,

Journal articles | 2016

Munier CML; van Bockel D; Bailey M; Ip S; Xu Y; Alcantara S; Liu SM; Denyer G; Kaplan W; Suzuki K; Croft N; Purcell A; Tscharke D; Cooper DA; Kent SJ; Zaunders JJ; Kelleher AD, 2016, 'The primary immune response to Vaccinia virus vaccination includes cells with a distinct cytotoxic effector CD4 T-cell phenotype', Vaccine, 34, pp. 5251 - 5261,

Journal articles | 2013

Ladell K; Hashimoto M; Iglesias MC; Wilmann PG; McLaren JE; Gras S; Chikata T; Kuse N; Fastenackels S; Gostick E; Bridgeman JS; Venturi V; Arkoub ZA; Agut H; van Bockel DJ; Almeida JR; Douek DC; Meyer L; Venet A; Takiguchi M; Rossjohn J; Price DA; Appay V, 2013, 'A Molecular Basis for the Control of Preimmune Escape Variants by HIV-Specific CD8+ T Cells', Immunity, 38, pp. 425 - 436,

Journal articles | 2013

Zaunders J; van Bockel D, 2013, 'Innate and Adaptive Immunity in Long-Term Non-Progression in HIV Disease', Frontiers in Immunology, 4,

Journal articles | 2009

Seddiki N; Sasson SC; Santner-Nanan B; Munier M; Van Bockel DJ; Ip S; Marriott D; Pett SL; Nanan R; Cooper DA; Zaunders J; Kelleher AD, 2009, 'Proliferation of weakly suppressive regulatory CD4+ T cells is associated with over-active CD4+ T-cell responses in HIV-positive patients with mycobacterial immune restoration disease', European Journal of Immunology, 39, pp. 391 - 403,

Journal articles | 2009

Venturi V; Chin HY; Asher TE; Ladell K; Scheinberg P; Bornstein E; Van Bockel D; Kelleher AD; Douek DC; Price DA; Davenport MP, 2009, 'TCR β-chain sharing in human CD8+ T cell responses to cytomegalovirus and EBV', Journal of Immunology, 181, pp. 7853 - 7862,

Journal articles | 2008

Streeck H; Van Bockel DJ; Kelleher AD, 2008, 'T-cell responses in primary HIV-1 infection. .', Current opinion in HIV & AIDS, 3, pp. 52 - 59

Journal articles | 2008

Venturi V; Chin HY; Asher TE; Ladell K; Scheinberg P; Bornstein E; van Bockel D; Kelleher AD; Douek DC; Price DA; Davenport MP, 2008, 'TCR beta-chain sharing in human CD8+ T cell responses to cytomegalovirus and EBV', Journal of Immunology, 181, pp. 7853 - 7862

Journal articles | 2007

Venturi V; Chin H; Asher T; Ladell K; Scheinberg P; Bornstein E; Van Bockel DJ; Kelleher AD; Douek DC; Price DA; Davenport MP, 2007, 'T cell receptor b-chain sharing in human CD8+ T cell responses to cytomegalovirus and Epstein-Barr virus', Journal of Immunology, 181, pp. 7853 - 7862

Journal articles | 2007

van Bockel D; Price DA; Asher TE; Venturi V; Suzuki K; Warton K; Davenport MP; Cooper DA; Douek DC; Kelleher AD, 2007, 'Validation of RNA-based molecular clonotype analysis for virus-specific CD8+ T-cells in formaldehyde-fixed specimens isolated from peripheral blood', Journal of Immunological Methods, 326, pp. 127 - 138,

Journal articles | 2005

Ammaranond P; Zaunders J; Satchell C; Van Bockel DJ; Cooper DA; Kelleher AD, 2005, 'A new variant cytotoxic T lymphocyte escape mutation in HLA-B27-positive individuals infected with HIV type 1', AIDS Research and Human Retroviruses, 21, pp. 395 - 397
Conference Abstracts | 2019

Polizzotto M; Van Bockel D; Law C; Roberts J; Buckland G; Just S; Comben S; Hillman R; Gilson R; Pett S; Poynten M; Law M; Kelleher A; Emery S, 2019, 'Clearance of HPV anal premalignant lesions and modulation of systemic immune responses to HPV oncogenes with low dose pomalidomide', in ANNALS OF ONCOLOGY, OXFORD UNIV PRESS, SWITZERLAND, Geneva, Vol. 30, presented at Immuno-Oncology Congress of the European-Society-for-Medical-Oncology (ESMO), SWITZERLAND, Geneva, 11 December 2019 - 14 December 2019,

Conference Abstracts | 2016

Munier CML; Bailey M; Ip S; Xu Y; Alcantara S; Liu SM; van Bockel D; Suzuki K; Cooper DA; Kent SJ; Zaunders JJ; Kelleher AD, 2016, 'The primary immune response to vaccinia virus vaccination includes cells with a distinct cytotoxic effector CD4 T cell phenotype', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY-BLACKWELL, AUSTRALIA, Melbourne, Vol. 46, pp. 676 - 677, presented at International Congress of Immunology (ICI), AUSTRALIA, Melbourne, 21 August 2016 - 26 August 2016

Conference Papers | 2005

Van Bockel DJ; Suzuki K; Warton K; Ammaranond P; Douek D; La Gruta N; Munier M; McGinley C; Nallaiah K; Stanley K; Turner SJ; Zaunders J; Cooper DA; Kelleher AD, 2005, 'TCR clonotypic analysis of CMV antigen-specific CD8+ T-cells from formaldehyde fixed peripheral blood', in Tissue Antigens, Blackwell Munksgaard, pp. 573 - 574

October (2024): Untangling the inherited and acquired host determinants predicting progression and persistence of HPV-driven anal disease (St Vincent's Clinic Foundation Research Grant) - $50,000

October (2023): Assessment of proviral reservoir characteristics in early HIV infection (St Vincent's Clinic Foundation Research Grant) - $50,000

December (2021): Characterisation and therapeutic harnessing of CD8+ tissue resident memory T (TRM) cell response to high-risk human papillomavirus (HPV)-associated anal squamous intraepithelial lesions (SIL) in the setting of human immunodeficiency virus (HIV) co-infection (National Institutes of Health (NIH), Notification of Special Interest R21 grant) - $450,000AUD

Fundamental basic research and clinical application to address the effect of standard treatment and experimental immunotherapies for infections (and vaccinations) including HPV, HIV and tuberculosis. Extensive experience in the field of immunovirology, lead in the development and completion of multiple national/international clinical trial projects requiring precise laboratory investigations.

My Research Supervision

Currently, I am supervising an HDR candidate to completion within a programme to understand the determinants of HIV-1 viral reservoir dissemination during early and chronic infection. The model tested is testing the effect of integrase-inhibitor (INSTI) therapy upon seeding of the HIV-1 reservoir in treatment naïve participants.

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